High conservation level of CD8+ T cell immunogenic regions within an unusual H1N2 human influenza variant
Identifieur interne : 000470 ( Main/Exploration ); précédent : 000469; suivant : 000471High conservation level of CD8+ T cell immunogenic regions within an unusual H1N2 human influenza variant
Auteurs : Naomi Komadina [Australie] ; Sergio M. Qui Ones-Parra [Australie] ; Katherine Kedzierska [Australie] ; James M. Mccaw [Australie] ; Anne Kelso [Australie] ; Karin Leder [Australie] ; Jodie Mcvernon [Australie]Source :
- Journal of Medical Virology [ 0146-6615 ] ; 2016-10.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (immunologie), Déterminants antigéniques des lymphocytes T, Grippe humaine (immunologie), Humains, Infections à Orthomyxoviridae (immunologie), Infections à Orthomyxoviridae (virologie), Lymphocytes T cytotoxiques (immunologie), Peptides (immunologie), Protection croisée, Protéines de liaison à l'ARN (génétique), Protéines de liaison à l'ARN (immunologie), Protéines du core viral (génétique), Protéines du core viral (immunologie), Sous-type H1N1 du virus de la grippe A (), Sous-type H1N1 du virus de la grippe A (immunologie), Sous-type H1N2 du virus de la grippe A (génétique), Sous-type H1N2 du virus de la grippe A (immunologie), Sous-type H3N2 du virus de la grippe A (), Sous-type H3N2 du virus de la grippe A (immunologie).
- MESH :
- génétique : Protéines de liaison à l'ARN, Protéines du core viral, Sous-type H1N2 du virus de la grippe A.
- immunologie : Anticorps antiviraux, Grippe humaine, Infections à Orthomyxoviridae, Lymphocytes T cytotoxiques, Peptides, Protéines de liaison à l'ARN, Protéines du core viral, Sous-type H1N1 du virus de la grippe A, Sous-type H1N2 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A.
- virologie : Infections à Orthomyxoviridae.
- Animaux, Déterminants antigéniques des lymphocytes T, Humains, Protection croisée, Sous-type H1N1 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A.
English descriptors
- KwdEn :
- Animals, Antibodies, Viral (immunology), Cross Protection, Epitopes, T-Lymphocyte, Humans, Influenza A Virus, H1N1 Subtype (chemistry), Influenza A Virus, H1N1 Subtype (immunology), Influenza A Virus, H1N2 Subtype (genetics), Influenza A Virus, H1N2 Subtype (immunology), Influenza A Virus, H3N2 Subtype (chemistry), Influenza A Virus, H3N2 Subtype (immunology), Influenza, Human (immunology), Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (virology), Peptides (immunology), RNA-Binding Proteins (genetics), RNA-Binding Proteins (immunology), T-Lymphocytes, Cytotoxic (immunology), Viral Core Proteins (genetics), Viral Core Proteins (immunology).
- MESH :
- chemical , genetics : RNA-Binding Proteins, Viral Core Proteins.
- chemical , immunology : Antibodies, Viral, Peptides, RNA-Binding Proteins, Viral Core Proteins.
- chemistry : Influenza A Virus, H1N1 Subtype, Influenza A Virus, H3N2 Subtype.
- genetics : Influenza A Virus, H1N2 Subtype.
- immunology : Influenza A Virus, H1N1 Subtype, Influenza A Virus, H1N2 Subtype, Influenza A Virus, H3N2 Subtype, Influenza, Human, Orthomyxoviridae Infections, T-Lymphocytes, Cytotoxic.
- virology : Orthomyxoviridae Infections.
- Animals, Cross Protection, Epitopes, T-Lymphocyte, Humans.
Abstract
Current seasonal influenza vaccines require regular updates due to antigenic drift causing loss of effectiveness and therefore providing little or no protection against novel influenza A subtypes. Next generation vaccines capable of eliciting CD8+ T cell (CTL) mediated cross‐protective immunity may offer a long‐term alternative strategy. However, measuring pre‐ and existing levels of CTL cross‐protection in humans is confounded by differences in infection histories across individuals. During 2000–2003, H1N2 viruses circulated persistently in the human population for the first time and we hypothesized that the viral nucleoprotein (NP) contained novel CTL epitopes that may have contributed to the survival of the viruses. This study describes the immunogenic NP peptides of H1N1, H2N2, and H3N2 influenza viruses isolated from humans over the past century, 1918–2003, by comparing this historical dataset to reference NP peptides from H1N2 that circulated in humans during 2000–2003. Observed peptides sequences ranged from highly conserved (15%) to highly variable (12%), with variation unrelated to reported immunodominance. No unique NP peptides which were exclusive to the H1N2 viruses were noted. However, the virus had inherited the NP from a recently emerged H3N2 variant containing novel peptides, which may have assisted its persistence. Any advantage due to this novelty was subsequently lost with emergence of a newer H3N2 variant in 2003. Our approach has potential to provide insight into the population context in which influenza viruses emerge, and may help to inform immunogenic peptide selection for CTL‐inducing influenza vaccines. J. Med. Virol. 88:1725–1732, 2016. © 2016 Wiley Periodicals, Inc.
Url:
DOI: 10.1002/jmv.24516
Affiliations:
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T-Lymphocyte</term><term>Humans</term><term>Influenza A Virus, H1N1 Subtype (chemistry)</term><term>Influenza A Virus, H1N1 Subtype (immunology)</term><term>Influenza A Virus, H1N2 Subtype (genetics)</term><term>Influenza A Virus, H1N2 Subtype (immunology)</term><term>Influenza A Virus, H3N2 Subtype (chemistry)</term><term>Influenza A Virus, H3N2 Subtype (immunology)</term><term>Influenza, Human (immunology)</term><term>Orthomyxoviridae Infections (immunology)</term><term>Orthomyxoviridae Infections (virology)</term><term>Peptides (immunology)</term><term>RNA-Binding Proteins (genetics)</term><term>RNA-Binding Proteins (immunology)</term><term>T-Lymphocytes, Cytotoxic (immunology)</term><term>Viral Core Proteins (genetics)</term><term>Viral Core Proteins (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antiviraux (immunologie)</term><term>Déterminants antigéniques des lymphocytes T</term><term>Grippe humaine (immunologie)</term><term>Humains</term><term>Infections à Orthomyxoviridae (immunologie)</term><term>Infections à Orthomyxoviridae (virologie)</term><term>Lymphocytes T cytotoxiques (immunologie)</term><term>Peptides (immunologie)</term><term>Protection croisée</term><term>Protéines de liaison à l'ARN (génétique)</term><term>Protéines de liaison à l'ARN (immunologie)</term><term>Protéines du core viral (génétique)</term><term>Protéines du core viral (immunologie)</term><term>Sous-type H1N1 du virus de la grippe A ()</term><term>Sous-type H1N1 du virus de la grippe A (immunologie)</term><term>Sous-type H1N2 du virus de la grippe A (génétique)</term><term>Sous-type H1N2 du virus de la grippe A (immunologie)</term><term>Sous-type H3N2 du virus de la grippe A ()</term><term>Sous-type H3N2 du virus de la grippe A (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>RNA-Binding Proteins</term><term>Viral Core Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Viral</term><term>Peptides</term><term>RNA-Binding Proteins</term><term>Viral Core Proteins</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza A Virus, H3N2 Subtype</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A Virus, H1N2 Subtype</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Protéines de liaison à l'ARN</term><term>Protéines du core viral</term><term>Sous-type H1N2 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps antiviraux</term><term>Grippe humaine</term><term>Infections à Orthomyxoviridae</term><term>Lymphocytes T cytotoxiques</term><term>Peptides</term><term>Protéines de liaison à l'ARN</term><term>Protéines du core viral</term><term>Sous-type H1N1 du virus de la grippe A</term><term>Sous-type H1N2 du virus de la grippe A</term><term>Sous-type H3N2 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term><term>Influenza A Virus, H1N2 Subtype</term><term>Influenza A Virus, H3N2 Subtype</term><term>Influenza, Human</term><term>Orthomyxoviridae Infections</term><term>T-Lymphocytes, Cytotoxic</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à Orthomyxoviridae</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cross Protection</term><term>Epitopes, T-Lymphocyte</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Déterminants antigéniques des lymphocytes T</term><term>Humains</term><term>Protection croisée</term><term>Sous-type H1N1 du virus de la grippe A</term><term>Sous-type H3N2 du virus de la grippe A</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Current seasonal influenza vaccines require regular updates due to antigenic drift causing loss of effectiveness and therefore providing little or no protection against novel influenza A subtypes. Next generation vaccines capable of eliciting CD8+ T cell (CTL) mediated cross‐protective immunity may offer a long‐term alternative strategy. However, measuring pre‐ and existing levels of CTL cross‐protection in humans is confounded by differences in infection histories across individuals. During 2000–2003, H1N2 viruses circulated persistently in the human population for the first time and we hypothesized that the viral nucleoprotein (NP) contained novel CTL epitopes that may have contributed to the survival of the viruses. This study describes the immunogenic NP peptides of H1N1, H2N2, and H3N2 influenza viruses isolated from humans over the past century, 1918–2003, by comparing this historical dataset to reference NP peptides from H1N2 that circulated in humans during 2000–2003. Observed peptides sequences ranged from highly conserved (15%) to highly variable (12%), with variation unrelated to reported immunodominance. No unique NP peptides which were exclusive to the H1N2 viruses were noted. However, the virus had inherited the NP from a recently emerged H3N2 variant containing novel peptides, which may have assisted its persistence. Any advantage due to this novelty was subsequently lost with emergence of a newer H3N2 variant in 2003. Our approach has potential to provide insight into the population context in which influenza viruses emerge, and may help to inform immunogenic peptide selection for CTL‐inducing influenza vaccines. J. Med. Virol. 88:1725–1732, 2016. © 2016 Wiley Periodicals, Inc.</div></front></TEI><affiliations><list><country><li>Australie</li></country><region><li>Victoria (État)</li></region><settlement><li>Melbourne</li></settlement><orgName><li>Université de Melbourne</li></orgName></list><tree><country name="Australie"><noRegion><name sortKey="Komadina, Naomi" sort="Komadina, Naomi" uniqKey="Komadina N" first="Naomi" last="Komadina">Naomi Komadina</name></noRegion><name sortKey="Kedzierska, Katherine" sort="Kedzierska, Katherine" uniqKey="Kedzierska K" first="Katherine" last="Kedzierska">Katherine Kedzierska</name><name sortKey="Kedzierska, Katherine" sort="Kedzierska, Katherine" uniqKey="Kedzierska K" first="Katherine" last="Kedzierska">Katherine Kedzierska</name><name sortKey="Kelso, Anne" sort="Kelso, Anne" uniqKey="Kelso A" first="Anne" last="Kelso">Anne Kelso</name><name sortKey="Kelso, Anne" sort="Kelso, Anne" uniqKey="Kelso A" first="Anne" last="Kelso">Anne Kelso</name><name sortKey="Kelso, Anne" sort="Kelso, Anne" uniqKey="Kelso A" first="Anne" last="Kelso">Anne Kelso</name><name sortKey="Komadina, Naomi" sort="Komadina, Naomi" uniqKey="Komadina N" first="Naomi" last="Komadina">Naomi Komadina</name><name sortKey="Komadina, Naomi" sort="Komadina, Naomi" uniqKey="Komadina N" first="Naomi" last="Komadina">Naomi Komadina</name><name sortKey="Leder, Karin" sort="Leder, Karin" uniqKey="Leder K" first="Karin" last="Leder">Karin Leder</name><name sortKey="Leder, Karin" sort="Leder, Karin" uniqKey="Leder K" first="Karin" last="Leder">Karin Leder</name><name sortKey="Mccaw, James M" sort="Mccaw, James M" uniqKey="Mccaw J" first="James M." last="Mccaw">James M. Mccaw</name><name sortKey="Mccaw, James M" sort="Mccaw, James M" uniqKey="Mccaw J" first="James M." last="Mccaw">James M. Mccaw</name><name sortKey="Mcvernon, Jodie" sort="Mcvernon, Jodie" uniqKey="Mcvernon J" first="Jodie" last="Mcvernon">Jodie Mcvernon</name><name sortKey="Mcvernon, Jodie" sort="Mcvernon, Jodie" uniqKey="Mcvernon J" first="Jodie" last="Mcvernon">Jodie Mcvernon</name><name sortKey="Qui Ones Arra, Sergio M" sort="Qui Ones Arra, Sergio M" uniqKey="Qui Ones Arra S" first="Sergio M." last="Qui Ones-Parra">Sergio M. Qui Ones-Parra</name><name sortKey="Qui Ones Arra, Sergio M" sort="Qui Ones Arra, Sergio M" uniqKey="Qui Ones Arra S" first="Sergio M." last="Qui Ones-Parra">Sergio M. Qui Ones-Parra</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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